Integrated pipeline for mass spectrometry-based discovery and confirmation of biomarkers demonstrated in a mouse model of breast cancer
JR Whiteaker, H Zhang, L Zhao, P Wang… - Journal of proteome …, 2007 - ACS Publications
Despite their potential to impact diagnosis and treatment of cancer, few protein biomarkers
are in clinical use. Biomarker discovery is plagued with difficulties ranging from
technological (inability to globally interrogate proteomes) to biological (genetic and
environmental differences among patients and their tumors). We urgently need paradigms
for biomarker discovery. To minimize biological variation and facilitate testing of proteomic
approaches, we employed a mouse model of breast cancer. Specifically, we performed LC …
are in clinical use. Biomarker discovery is plagued with difficulties ranging from
technological (inability to globally interrogate proteomes) to biological (genetic and
environmental differences among patients and their tumors). We urgently need paradigms
for biomarker discovery. To minimize biological variation and facilitate testing of proteomic
approaches, we employed a mouse model of breast cancer. Specifically, we performed LC …
